Why is CBD isolate ineffective?

CBD isolate refers to pure cannabidiol, which has been extracted from the hemp or cannabis plant and isolated or stripped from all other cannabinoids and compounds naturally found in the plant.  While CBD isolate is generally considered safe and non-intoxicating, it may have limited bioavailability when consumed on its own. 

Bioavailability is a term that refers to the amount and rate at which a substance is absorbed into the bloodstream and made available for use by the body. CBD isolate has low bioavailability because it is a hydrophobic (water-insoluble) compound, and the body’s digestive system is primarily water-based. When CBD isolate is consumed in any form orally, it must first pass through the digestive system and then the liver, where it will be partially broken down and metabolized before reaching the bloodstream. This process can limit the amount of CBD isolate that actually reaches the bloodstream and can make it less effective or perhaps not effective at all.